Efficiency of exogenous quinolinic acid as niacin in rats.
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چکیده
منابع مشابه
Quinolinic acid accumulation in the conversion of 3-hydroxyanthranilic acid to niacin in Neurospora.
3-Hydroxyanthranilic acid has been shown to serve as a natural precursor of niacin in Neurospora. 12 Little. information, however, has been obtained concerning the mechanism whereby the aromatic ring of 3hydroxyanthranilic acid is converted to the pyridine ring of niacin. The present paper will deal with this latter problem. Singal, et al.,I have reported that the administration of tryptophan t...
متن کاملExcess dietary lysine increases growth of chicks fed niacin-deficient diets, but dietary quinolinic acid has no niacin-sparing activity.
Catabolism of Trp and Lys produces alpha-ketoadipic acid as an intermediary metabolite. An alternate pathway of Trp turnover leads to NAD synthesis. We hypothesized that excess Lys might improve the conversion of Trp to niacin by causing a buildup of alpha-ketoadipic acid, thereby endproduct inhibiting the main Trp catabolic pathway and resulting in more niacin synthesis from Trp. Six bioassays...
متن کاملSystemic approaches to modifying quinolinic acid striatal lesions in rats.
Quinolinic acid (QA) is an endogenous excitotoxin present in mammalian brain that reproduces many of the histologic and neurochemical features of Huntington's disease (HD). In the present study we have examined the ability of a variety of systemically administered compounds to modify striatal QA neurotoxicity. Lesions were assessed by measurements of the intrinsic striatal neurotransmitters sub...
متن کاملChronic quinolinic acid lesions in rats closely resemble Huntington's disease.
We previously found a relative sparing of somatostatin and neuropeptide Y neurons 1 week after producing striatal lesions with NMDA receptor agonists. These results are similar to postmortem findings in Huntington's disease (HD), though in this illness there are two- to threefold increases in striatal somatostatin and neuropeptide Y concentrations, which may be due to striatal atrophy. In the p...
متن کاملQuinolinic Acid Metabolism
Since the observation (1) that tryptophan and nicotinic acid are mutually interchangeable, within limits, in supporting the growth of rats, considerable evidence has accumulated which indicates that biosynthesis of nicotinic acid can proceed from tryptophan (2-5). Unequivocal evidence for this transformation was provided by the experiments of Heidelberger et al. (6) who fed labeled tryptophan @...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1986
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.50.2025